Resources Technical Documents DRAQ7 and Annexin V
Technical documents description.....
Live, intact cell impermeant DNA dyes are commonly combined with Annexin V (which reports membrane inversion) to give information about the progression of apoptosis.
As shown in the figure below, DRAQ7TM (top & middle series) performs in an equivalent manner to propidium iodide (PI, bottom series), to report the onset of membrane leakiness caused by increasing doses of VP-16.
Plus, DRAQ7TM offers new possibilities as a far-red, non-enhancing DNA binding dye. Using both log and linear displays, further discrete sub-populations can be identified. Also, unlike PI, DRAQ7TM will permit several fluorescent parameters to be measured in parallel; 4 with blue laser excitation alone.
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