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Live Danio in CyGEL Sustain

HTS / HCS Screening nuclear visualisation

DRAQ5™ is ideal for nuclear localization in HTS/HCS assays...

Why do most serious screeners use DRAQ5™?

 

  1. See both nucleus and cytoplasm compartments for translocation events and to assess morphological changes (toxicity)
  2. Lower hardware costs - Excitation in visible range - lower cost HeNe laser systems cf. UV lasers
  3. See all library members  - No white-out by UV-excited test compounds (ca. 10-15% of libraries) 
  4. Faster assay acquisition with GFP targets Emission in far-red - no spectral overlap with majority of vis. range EXFPs
  5. Simple labelling protocol - Live (or fixed) cells are efficiently labelled in minutes, in most buffer systems
  6. See the MDR cells too - DRAQ5™ is NOT pumped out of MDR cells so they will be visible to the imager